The 7 Best Tires for the Mercedes E350

#1. General Altimax RT43 – Best Overall

Why is the General Altimax RT43 our top pick for the Mercedes E350?

Start with a comfortable year-round performance. This model’s dual-layer tread compound makes sure that its ride remains as plush under the sun as in rainy conditions. You can thus count on this tire to keep your E350’s ride noise- and vibration-free.

Next comes its ability to wear evenly. This means that the RT43 will provide consistent traction throughout its road life. Also, when a tire wears unevenly, its fuel consumption skyrockets, a problem you won’t be facing with this popular grand touring tire.

You may also appreciate that this model comes with a 75,000-mile treadwear warranty. As a driver for over two decades, I can assure you that such a guarantee means you can easily get 4 to 5 years out of the investment you’d be making in this model.

Which is great news once you look at its price tag. While the RT43 is by no means cheap, its asking price is 10-20% lower than what the likes of Michelin charge for their premium tires. This is huge since the difference in performance isn’t that much.

#2. Bridgestone Turanza QuietTrack – Best Grand Touring

The Bridgestone Turanza QuietTrack rivals our top pick on various counts.

Like the Altimax RT43, this model eats smaller imperfections, helping you get the famed ride quality E350 is famous for. It is also insanely quiet – I can vouch for this grand touring tire making little to no noise at speeds below 80 miles per hour.

Its wet performance can also stand up to RT43’s. The Turanza QuietTrack has multiple grooves for quick and effective water evacuation and a reduced risk of hydroplaning. It also has the biting edges needed to safely carry you from point A to point B on snow.

Unlike the RT43, this model takes no prisoners on performance.

Whether you’re driving on dry or wet roads, the steering responsiveness and feedback will be top-notch. The same could be said with its high-speed stability, which is also brilliant. In fact, were it not for its relatively high asking price, this tire would have been our top pick.

#3. Pirelli Cinturato P7 All Season Plus II – Best All-Season

The Pirelli Cinturato P7 checks several boxes for E350 drivers.

A high-silica tread compound enables this tire to offer supreme wet traction, distinguishing this tire from rival all-season touring tires. Plus, since the rubber is molded into an asymmetric tread pattern, better traction on dry and snow surfaces is also guaranteed.

Having used this model’s predecessor, I always believed any upcoming tire would struggle to match its fuel efficiency. Fortunately, the P7 All-Season Plus II has proved me wrong. Thanks to its 5% larger contact area, this model consumes even less fuel than its precursor.

Tread life is one area where this tire hasn’t improved over its predecessor. But that isn’t something that should prove to be a deal-breaker. Both tires come with a 70,000-mile mileage warranty, which should translate into 4 to 5 years of road life if you drive conservatively.

#4. Bridgestone Potenza RE980 AS – Best All-Season

Just as many people think that the Mercedes E350 is a complete car, so are there are drivers thinking performance tires cannot get any better than the Potenza RE980AS.

Having seen this tire’s performance from the passenger seat, I agree with the above sentiment. The RE980 AS is one of those tires that justify the word ‘exceptional’ when it’s used to describe their cornering grip. Its straight-line tracking and high-speed stability are equally great.

Thanks to its asymmetric tread pattern, this model also delivers a sure-footed driving experience on wet and dry roads. Plus, the sight of multiple circumferential grooves in its tread area should convince you that it won’t skid or slip over wet or light snowy surfaces.

Steering feedback is another area where this model shines. Its continuous center rib and multiple shoulder blocks ensure you get the maximum feel of what is going down there on the road. Small wonder, then, that this model has the annoying ‘ability’ to wear unevenly.

#5. Goodyear Assurance WeatherReady – Best All-Weather

The Goodyear Assurance WeatherReady is one of my favorite all-weather tires. It can become yours too, provided you pair it with your ES350. Here’s why I’m so confident.

This model delivers outstanding traction on dry and wet roads, with a steering feedback you rarely expect from tires in this category. Plus, thanks to its optimized symmetric tread pattern, it will enhance not hurt your E350’s already plush ride quality.

It will also impress you with its wet performance. Goodyear has equipped this model with its proprietary traction grooves to help it tackle the worst of weather conditions. As such, you won’t have to take your foot off the accelerator in the rain.

You can also count on this model to provide consistent traction throughout its road life, something not many tires are capable of offering. Another thing you can rely on this model to do is offer excellent performance in mild wintry conditions.

Unfortunately, there is one area where the WeatherReady could do better. Its 60,000-mile treadwear warranty is at least 10,000 miles shorter than average.  

#6. Goodyear Eagle F1 Asymmetric 3 ROF – Best Run-Flat

Some Mercedes E350 trims come with run-flat tires from the factory. If that’s the case with the trim you’re driving, consider the Eagle F1 Asymmetric 3 ROF.

Goodyear has reinforced this model’s walls vis-à-vis its ‘standard’ colleague. It has also provided it with a relatively tougher tread compound. The result? The Eagle F1 Asymmetric 3 can be safely driven at speeds of up to 50 mph per for up to 50 miles with zero air pressure.

Given that it’s a high-performance tire, excellent cornering performance is a given. This model also boasts short braking distances, a boon on dry roads. Plus, unlike the majority of run flat tires, the F1 Asymmetric 3 ROF doesn’t growl at high speeds, even when fully flat.

That isn’t to say that this model is faultless. Its wet traction is sub-par when compared with standard performance or high-performance tires. However, to compensate for this shortcoming, this model delivers outstanding responsiveness, even for an ROF tire.

All in all, if you could make do with average wet traction in return for excellent steering feedback and the knowledge that this model won’t leave you stranded in the middle of nowhere (as it can be run flat), go for the Eagle F1 Asymmetric 3.

#7. Michelin X-Ice XI3 – Best Winter Tires

The Michelin X-Ice Xi3 has what it takes to safely carry your E350 from point A to point B in harsh wintry conditions. Aside from that, it comes with a 40,000-mile treadwear warranty, a rarity for any winter tire (just ask Bridgestone, whose flagship winter tire comes with no tread guarantee).  

Michelin’s Flex-Ice tread compound sees to it that this tire’s rubber stays flexible in sub-zero temperatures. This, in turn, gives the XI3 the power to dig through sheets of snow and ice and grip the hard surface underneath. The result is excellent and consistent traction.

Cross-Z sipes do what the tread compound fails to – they help the XI3 plow through snow and ice. This tire also features multiple circumferential grooves to help with water evacuation. As such, the risk of hydroplaning or skidding on slipping on wet/winter roads is minimal.

Lastly, there are two areas where this model sets itself apart from premium winter tires. The first of which is the above treadwear warranty (most winter tires receive zero backing from their manufacturers). The second, meanwhile, is its ability to consume less gas than competition.